It would be more pythonic, if QFile would have _enter_ + _exit_ to be also full-featured py file object (=mimic io.FileIO interface a bit).

Then you can write the dynamic .ui file loading:

loader=QtUiTools.QUiLoader()
try:
    with QtCore.QFile("path-to-ui.ui") as f:
        window = loader.load(f)
        return window
except Exception as e:
    logger.error("... %s : %s", type(e), e)

(Improvemement to https://bit.ly/3mapkTk)