If you link with a framework via "LIBS += -framework test" and add "CONFIG += serialport" to your project file the "-framework" is removed from the resulting LIBS variable, causing the build to fail.

The problem is the following line in serialport.prf: "LIBS -= -framework QtSerialPort$${QT_LIBINFIX}" which removes all occurrences of -framework from the list.

I have added a patch, which fixes the problem.
If you think this solution is feasible I can push it to gerrit.