When creating an empty qmake project with the wizard, and adding minimal compilable application, building it succeeds but running gives an error:

Starting C:\qtprojects\build-untitled16-Desktop_Qt_5_10_1_MSVC2017_64bit-Debug\untitled16.exe...
Executable C:\qtprojects\build-untitled16-Desktop_Qt_5_10_1_MSVC2017_64bit-Debug\untitled16.exe does not exist.

This is a regression from 4.5.2 to 4.6.

In Projects -> <selected_kit> -> Run, the executable location is set as:

C:\qtprojects\build-untitled16-Desktop_Qt_5_10_1_MSVC2017_64bit-Debug\untitled16.exe

when the executable is in fact properly build to the "debug" sub directory:

C:\qtprojects\build-untitled16-Desktop_Qt_5_10_1_MSVC2017_64bit-Debug\debug\untitled16.exe

Creating other project templates do not seem to suffer from this same issue.